Construction and properties of venlafaxine hydrochloride sustained release system based on hollow mesoporous silica microspheres--颗粒学报PARTICUOLOGY

Liang, C., Shi, L., Chen, Z., Zhou, L., Zhang, Z., & Zhang, G. (2024). Construction and properties of venlafaxine hydrochloride sustained release system based on hollow mesoporous silica microspheres. Particuology, 86, 205-210. https://doi.org/10.1016/j.partic.2023.06.011

Construction and properties of venlafaxine hydrochloride sustained release system based on hollow mesoporous silica microspheres

Chenjing Liang ^a, Lingling Shi ^a, Zhengguo Chen ^a, Lan Zhou ^{b c}, Zhaoxia Zhang ^a, Guoqing Zhang ^{a c *}

a School of Materials Science and Engineering, Zhejiang Sci-tech University, Hangzhou, China
b College of Textile Science and Engineering, Zhejiang Sci-tech University, Hangzhou, China
c Zhejiang Provincial Innovation Center of Advanced Textile Technology, Shaoxing, China

10.1016/j.partic.2023.06.011

Volume 86, March 2024, Pages 205-210

Received 16 February 2023, Revised 15 June 2023, Accepted 16 June 2023, Available online 3 July 2023, Version of Record 7 July 2023.

E-mail: zgq@zstu.edu.cn

Highlights

• A simpler preparation method of hollow mesoporous silica microspheres was developed.

• Sustained release system of venlafaxine hydrochloride was prepared with hollow silica as carrier.

• It provides a new idea for the sustained release of water-soluble drugs.

Abstract

The aim of this work is to develop a venlafaxine hydrochloride sustained release system based on hollow mesoporous silica microspheres (HMSMs). HMSMs were innovatively prepared with tetraethyl silicate (TEOS) as the precursor and volatile n-heptane as a soft template. The obtained HMSMs show a well-defined hollow structure with an average size of 967 nm and pore volume of 0.85 cm³/g, implying it is a potential drug carrier. Subsequently, venlafaxine hydrochloride (VF) was absorbed in the HMSMs with a content of 37.67% or so. The sustained release effect is further measured by the dissolution instrument at 37 °C and 50 rpm in ultrapure water. The results showed that the HMSMs/VF system shows good sustained release properties compared with sustained release tablets with hydroxypropyl methylcellulose as the main component. This HMSMs sustained release system appears to be a promising candidate for a sustained drug release.

Graphical abstract

Keywords

Hollow mesoporous silica microspheres (HMSMs); Venlafaxine hydrochloride; Drug loading; Sustained release

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