Current status and challenges in the application of microbial PHA particles--颗粒学报PARTICUOLOGY

Liu, J., Zhou, Z., Li, H., Yang, X., Wang, Z., Xiao, J., & Wei, D.-X. (2024). Current status and challenges in the application of microbial PHA particles. Particuology, 87, 286-302. https://doi.org/10.1016/j.partic.2023.08.011

Current status and challenges in the application of microbial PHA particles

Jiaxuan Liu ^{a 1}, Ziqi Zhou ^{a 1}, Haoru Li ^{a 1}, Xinyu Yang ^{a 1}, Zeyu Wang ^a, Jian Xiao ^c, Dai-Xu Wei ^{a b d *}

a Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China
b School of Clinical Medicine, Qujing Medical College, Qujing, 655000, China
c School of Physics and Electronic Information, Shangrao Normal University, Shangrao, 334001, China
d Zigong Affiliated Hospital of Southwest Medical University, Zigong Psychiatric Research Center, Zigong Institute of Brain Science, Zigong, 643002, China

10.1016/j.partic.2023.08.011

Volume 87, April 2024, Pages 286-302

Received 14 May 2023, Revised 31 July 2023, Accepted 10 August 2023, Available online 9 September 2023, Version of Record 26 September 2023.

E-mail: daviddxwei@163.com

Highlights

• Summarized the current status of PHA-based particles on micro- and nano-scale.

• Advantages of PHA particles applied to human health and biotechnology in tissue engineering.

• Challenges of PHA particles in the future.

Abstract

Polyhydroxyalkanoates (PHAs) are diversiform biopolyesters with a similar structure and different side chain groups, synthesized by a variety of microorganism. Due to their excellent biodegradability and biocompatibility, PHAs have been used for many applications, including medical implants, antibacterial agents and bioengineering. Nano-architecture is an emerging area for the use of PHAs. This review summarizes the current status and challenges of PHAs-based particles on the micro- and nano-scale, including their production, degradation, biological safety, and surface functionalization. We also focus on the applications of PHA particles in drug delivery systems, environment protection, tissue engineering, vaccine engineering, food science, biotechnology and cosmetics. Finally, the future development trends of PHAs-based particles are prospected.

Graphical abstract

Keywords

Polyhydroxyalkanoates (PHAs); Particles; Synthetic biology; Tissue engineering

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