Multifunctional polyeugenol-based nanoparticles with antioxidant and antibacterial properties--颗粒学报PARTICUOLOGY

Lan, Q., Zhang, X., Liang, J., Wang, W., Lv, L., He, J., . . . Qu, C. (2024). Multifunctional polyeugenol-based nanoparticles with antioxidant and antibacterial properties. Particuology, 87, 194-204. https://doi.org/10.1016/j.partic.2023.08.012

Multifunctional polyeugenol-based nanoparticles with antioxidant and antibacterial properties

Qiaoqiao Lan ^{a b}, Xuying Zhang ^a, Jiaming Liang ^b, Wei Wang ^a, Leili Lv ^a, Jiamin He ^b, Zefeng Wang^{b c *}, Chunsheng Qu ^a *

a The People's Hospital of Lishui, Lishui, 323000, China
b College of Ecology, Lishui University, Lishui, 323000, China
c R&D Center of Green Manufacturing New Materials and Technology of Synthetic Leather Sichuan University-Lishui University, Lishui, 323000, China

10.1016/j.partic.2023.08.012

Volume 87, April 2024, Pages 194-204

Received 11 February 2023, Revised 10 June 2023, Accepted 10 August 2023, Available online 9 September 2023, Version of Record 11 September 2023.

E-mail: shangk72@163.com; quchunsheng333@163.com

Highlights

• Nanospheres exhibited crosslinked structures in inside and entire heterogeneous structure, respectively.

• Nanospheres exhibited excellent adsorption which was dependent on surface area and presence of amino groups.

• Nanospheres exhibited high antioxidant activities and could effectively reduce intracellular ROS.

• Nanospheres showed excellent bactericidal activities and good biocompatibility.

Abstract

Over the past few decades, extensive scientific has been dedicated to polymer synthesis employing renewable resources. In this study, we devised and synthesized multifunctional polyeugenol-based nanoparticles, exhibiting remarkable antioxidant and antibacterial properties. The grafting of eugenol onto the nanoparticle surface was achieved via a thiol-ene chemical reaction with a grafting rate of 3.5%. To comprehend the properties of the synthesized nanoparticles, we employed Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and pyrolysis-gas chromatography mass spectrometry. Subsequent scanning electron microscopic and transmission electron microscopic analyses revealed the presence of a crosslinked structure within the polyeugenol-based nanoparticles, as well as a heterogeneous microsphere structure on the surface. Due to the inherent crosslinking structure, the polyeugenol-based nanoparticles demonstrated robust the resistance to solvents, as ascertained through thermogravimetric analysis and solvent resistance tests. Notably, nitrogen adsorption/desorption studies confirmed the adsorption capacity of the polyeugenol-based nanoparticles, rendering them potentially suitable for drug transport applications. Moreover, the assays for assessing cytocompatibility and reactive oxygen species scavenging activities demonstrated better performance of the eugenol-based nanoparticles compared to eugenol. Furthermore, the polyeugenol-based nanoparticles exhibited certain bactericidal activities against Escherichia coli, Staphylococcus aureus, and Fusobacterium nucleatum. Consequently, these observations indicated the nontoxic nature and expansive application prospects of the polyeugenol-based nanoparticles in the domains of medicine and food preservation. This work presented a pioneering concept for the development of antioxidant and antibacterial multifunctional polymer materials derived from eugenol.

Graphical abstract

Keywords

Polyeugenol-based nanoparticles; Bactericidal activities; Cytocompatibility

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