The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying--颗粒学报PARTICUOLOGY

Barranco-García, J. E., Caicedo, C., Jiménez-Regalado, E. J., Espinoza-González, C., Morales, G., Aguirre-Loredo, R. Y., & Fonseca-García, A. (2024). The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying. Particuology, 89, 1-10. https://doi.org/10.1016/j.partic.2023.10.004

The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

Juan Enrique Barranco-García^{a 1}, Carolina Caicedo^b, Enrique Javier Jiménez-Regalado ^c, Carlos Espinoza-González^{c 1}, Graciela Morales^c, Rocio Yaneli Aguirre-Loredo^{c d *}, Abril Fonseca-García^{c d *}

a Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca, Departamento de Química y Bioquímica, Avenida Ing. Víctor Bravo Ahuja No. 125, Esquina Calzada Tecnológico, 68030, Oaxaca, Mexico
b Faculty of Engineering, Unidad Central del Valle del Cauca (UCEVA), Carrera 17a 48-144, 763022, Tuluá, Colombia
c Centro de Investigación en Química Aplicada (CIQA), Blvd. Enrique Reyna Hermosillo 140, 25294, Saltillo, Coahuila, Mexico
d Investigadoras por México CONAHCYT-CIQA, Av. Insurgentes Sur 1562, Col. Crédito Constructor, 03940, Alcaldía Benito Juárez, CDMX, Mexico

10.1016/j.partic.2023.10.004

Volume 89, June 2024, Pages 1-10

Received 6 April 2023, Revised 11 September 2023, Accepted 5 October 2023, Available online 28 October 2023, Version of Record 5 December 2023.

E-mail: yaneli.aguirre@ciqa.edu.mx; abril.fonseca@ciqa.edu.mx

Highlights

• Starch-chitosan-Pluronic® F127 blends form microparticle powders by spray drying.

• The powders have low hydrophilicity, reflected in a low water activity.

• The microparticles showed a bowl-shaped morphology.

• The biopolymer blend with F127 at 3% (w/v) has the best yield.

• The biopolymer blend with F127 at 3% (w/v) showed the best thermal stability.

Abstract

Using biopolymers as wall materials in spray drying poses challenges, particularly in attaining flowability and thermal stability among their physicochemical properties. This paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer, commercially named Pluronic® F127. We aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying technique. Blends with a poloxamer concentration of 3% (w/v) demonstrated a notably higher yield, especially when compared to those with 0% and 1% concentrations. Microparticles with 3% and 5% (w/v) poloxamer displayed a narrower particle size distribution, with the 3% blend showing a superior yield attributed to arrangements of blend components that improve flowability. X-ray diffraction analysis showcased the characteristic peaks of A-type starch form, with shifts suggesting enhanced interactions between components. Microparticles with increased poloxamer content showed elevated thermal degradation temperatures, with the 3% blend registering a significant rise, opening avenues for encapsulating heat-sensitive bioactive. This study primarily focuses on the preparation and basic characterization of microparticles. It underscores the potential of blends with optimal poloxamer concentrations in microencapsulation, emphasizing further research to harness their capabilities thoroughly.

Graphical abstract

Keywords

Biopolymer; Starch; Chitosan; Pluronic® F127; Microparticles; Spray drying

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