Applications of artificial intelligence to lipid nanoparticle delivery (Open Access)--颗粒学报PARTICUOLOGY

Yuan, Y., Wu, Y., Cheng, J., Yang, K., Xia, Y., Wu, H., & Pan, X. (2024). Applications of artificial intelligence to lipid nanoparticle delivery. Particuology, 90, 88-97. https://doi.org/10.1016/j.partic.2023.11.014

Applications of artificial intelligence to lipid nanoparticle delivery (Open Access)

Ye Yuan ^{a 1 *}, Yuqi Wu ^{a 1}, Jiabei Cheng ^a, Kaiyuan Yang ^a, Yilin Xia ^a, Hongguang Wu ^b, Xiaoyong Pan ^a *

a Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Key Laboratory of System Control and Information Processing, Ministry of Education of China, China
b Songjiang Research Institute, Songjiang District Central Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

10.1016/j.partic.2023.11.014

Volume 90, July 2024, Pages 88-97

Received 25 October 2023, Revised 6 November 2023, Accepted 17 November 2023, Available online 25 November 2023, Version of Record 26 December 2023.

E-mail: yuanye_auto@sjtu.edu.cn; 2008xypan@sjtu.edu.cn

Highlights

• Discuss how artificial intelligence influences lipid nanoparticles’ design and optimization.

• Discuss lipid nanoparticles' applications in gene therapy and mRNA vaccine development.

• Discuss the application of artificial intelligence in targeted conjugations of lipid nanoparticles.

• Discuss the application of artificial intelligence in the design of ionizable lipids.

Abstract

Lipid nanoparticles (LNPs) are nanocarriers composed of four lipid components and can be used for gene therapy, protein replacement, and vaccine development. However, LNPs also face several challenges, such as toxicity, immune activation, and low delivery efficiency. To overcome these challenges, artificial intelligence can be used to optimize the design and formulation of LNPs, as well as to predict their properties and performance. Moreover, antibody-targeted conjugation can be used to enhance the specificity and selectivity of LNPs by attaching an antibody that recognizes a specific antigen on the cell surface to LNPs.

Graphical abstract

Keywords

Artificial intelligence; Lipid nanoparticles; Antibody; Targeted conjugation

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