Copper-based nanodots as efficient biomimetic antibiotics for the treatment of oral bacterial infections--颗粒学报PARTICUOLOGY

Li, Y., Tang, N., Zhao, L., Bao, X., Wang, Y., Wang, Z., & Hu, M. (2024). Copper-based nanodots as efficient biomimetic antibiotics for the treatment of oral bacterial infections. Particuology, 91, 190-201. https://doi.org/10.1016/j.partic.2024.03.003

Copper-based nanodots as efficient biomimetic antibiotics for the treatment of oral bacterial infections

Ying Li^{a 1}, Nan Tang^{b 1}, Lingling Zhao^{b 1}, Xingfu Bao^a, Yuzhuo Wang^a, Zhanxin Wang^a, Min Hu^a *

a Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun, China
b Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China

10.1016/j.partic.2024.03.003

Volume 91, August 2024, Pages 190-201

Received 26 February 2024, Revised 13 March 2024, Accepted 17 March 2024, Available online 24 March 2024, Version of Record 29 March 2024.

E-mail: humin@jlu.edu.cn

Highlights

• Copper-based nanodots were well synthesized by using a facile one-pot strategy.

• Copper-based nanodots held extremely low toxicity, good biocompatibility, as well as excellent Fenton-like catalytic activity.

• Copper-based nanodots were developed as efficient biomimetic antibiotics for various oral infection.

Abstract

Oral infectious diseases caused by a variety of pathogenic bacteria seriously affect the quality of life. However, these diseases remain a clinical challenge because of the lack of simple, safe, and universal prophylactics. To address these limitations, we synthesize CuO_x nanodots (CuO_x NDs) with excellent Fenton-like reaction activity and utilize them in the treatment of oral bacterial infections. Different from other complicated approaches, CuO_x NDs are rationally prepared using a facile one-pot aqueous synthesis. In the presence of H₂O₂, these well-developed CuO_x NDs can efficiently catalyze the generation of hydroxyl radicals (·OH) around oral pathogens, leading to the death of various bacteria. Meanwhile, results of biosafety indicate the high biocompatibility and extremely low toxicity of these CuO_x NDs. After understanding the admirable in vitro antibacterial effect of CuO_x NDs in the presence of H₂O₂, we further explore their in vivo antibacterial performance on several classical animal models including oral mucosal wound model, intragingival bacteria-infected model, and the periodontal infection model. As expected, these CuO_x NDs with wide-spectrum antibacterial activity can serve as high-performance antibacterial reagents for the treatment of various oral bacterial infections with the help of H₂O₂. In brief, current nanoplatform can act as efficient antibiotics against oral pathogens with broadening the biomedical applications of copper-based nanomaterials.

Graphical abstract

Keywords

Antibacterial treatment; Oral diseases; Fenton-like catalytic reaction; Reactive oxygen species

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