This study designs and analyzes two high-performance hybrid micromixers: a multi-channel type Mixer 1 and a super-efficient type Mixer 2. Mixer 1 integrates a tree-shape distributor with Split-and-Recombine (SAR) mixers, while Mixer 2 incorporates an additional tree-shape Focus mixer after the SAR mixers. Mixing performance was analyzed across a Reynolds number (Re) range of 0.5–120. The distributor, designed via entropy generation minimization, uniformly splits flow into eight outlets while preserving the inlet concentration distribution. The SAR unit significantly enhances transverse mass transport through Baker's transformation and secondary flows. Using over four SAR units yields >90 % efficiency across the entire Re range. The Focus mixer reduces fluid-layer thickness through bifurcation-merging processes and induces secondary flow; with four branching generations, its efficiency surpasses 90 % at Re > 10 and 99 % at Re > 35. In hybrid configurations with six SAR units, Mixer 1 exhibits a mixing efficiency dip to 95 % for Re = 6 across all outlets, exceeding 99 % for Re < 3 and Re > 8. Mixer 2 also shows a dip at Re = 6, but its minimum efficiency remains >97 %, validating its ultra-high-efficiency design.