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Volume 117
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A binary hydrogen-bonded organic framework reinforced biodegradable hydrogel composite for synergistic antibacterial therapy and controlled degradation
Jiaxuan Liu a, Peiyan Li b, Chenghao Zhang b, Hang Tian c, Peng Li a *
a State Key Laboratory of Porous Materials for Separation and Conversion, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, College of Smart Materials and Future Energy, Fudan University, Shanghai, 200438, China
b Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, School of Light Industry and Food Engineering, Guangxi University, Nanning, 530004, China
c School of Chemistry and Chemical Engineering, Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, Guangxi University, Nanning, 530004, China
10.1016/j.partic.2026.07.022
Volume 117, October 2026, Pages 534-541
Received 26 May 2026, Revised 23 July 2026, Accepted 26 July 2026, Available online 18 August 2026, Version of Record 26 August 2026.
E-mail: penglichem@fudan.edu.cn
Highlights

• First HOF-reinforced biodegradable hydrogel for wound dressing.

• FDU-HOF-22 enhances hydrogel toughness by 400% and reduces swelling.

• Composite achieves >99% bactericidal efficiency against E. coli.

• Spontaneous degradation under physiological conditions avoids residue.


Abstract

Antibiotic overuse and persistent material residue remain major challenges in the management of infected wounds. Herein, we report a biodegradable hydrogel composite reinforced by a binary hydrogen-bonded organic framework, designated FDU-HOF-22, for synergistic antibacterial therapy and controlled degradation. Through physical cross-linking, FDU-HOF-22 crystals were introduced into the polyvinyl alcohol (PVA)-based and cellulose nanofibers (CNFs) polymer network. The resulting composite exhibits a 399.46% increase in toughness, reduced swelling behavior, and spontaneous degradation under physiological conditions (pH 7.4, 37 °C). Benefiting from efficient singlet-oxygen generation at a rate of 7.47 mmol/g/h, the composite achieves >99% bactericidal efficiency against Escherichia coli. This work provides a new strategy for designing intelligent, biodegradable antibacterial composites for wound dressing applications.

Graphical abstract
Keywords
Hydrogen-bonded organic frameworks; Biodegradable hydrogels; Synergistic antibacterial therapy; Controlled degradation; Wound dressing; Reactive oxygen species
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